Focusrite

Focusrite Red 16Line Thunderbolt 3 Audio Interface

Thunderbolt 3phantom power

The Focusrite Red 16Line delivers studio-grade conversion and Red Evolution preamps in a single Thunderbolt 3 interface built for professional tracking sessions.

$4,499.99*
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*Price sourced from Amazon.com. Last updated:Jul 14, 2026.Price and availability are subject to change.

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Overview

The Focusrite Red 16Line is built for professional studios where signal chain integrity is non-negotiable — tracking rooms, post-production suites, and broadcast facilities running Pro Tools HD alongside networked Dante infrastructure. The Red Evolution preamps at its core are designed for transparency at the top of the gain range, delivering up to 63dB of headroom with individual phantom power, phase reverse, and high-pass filter per channel. What you hear through these preamps is a clean, resolved signal — acoustic instruments retain air and dimension, vocals sit in a mix without needing corrective EQ to flatten preamp coloration. The conversion itself is the headline: A/D and D/A stages that handle transient response with enough resolution that subtle dynamic decisions made at the mic level survive the digital round trip intact.

Connectivity is where the Red 16Line separates itself from single-protocol interfaces. Thunderbolt 3, Pro Tools | HD, and Dante run simultaneously without option cards — a level of routing flexibility that allows a single unit to anchor a hybrid studio feeding a local DAW, an HD system, and a Dante network all at once. The 16 D-sub line inputs and 16 line outputs integrate cleanly with traditional patchbay setups, and the dual-port Dante card maintains channel count at higher sample rates where competitors trim back. Two front-panel instrument inputs and dual headphone outputs with discrete monitoring handle engineer and producer cue mixes without adding a separate headphone amp. Under session pressure — long tracking days, last-minute routing changes, simultaneous overdub and mix sessions — the Red 16Line's architecture holds without the kind of driver instability or sync issues that surface in less mature interfaces.

Key Features

Connect to Pro Tools | HD, Thunderbolt computers and Dante simultaneously without option cards

High-performance audio conversion

Ultra-low round trip latency to track through plug-ins and record virtual instruments in real time

16-line inputs on D-sub, coupled with 16 line outputs and two main monitor outputs

Two digitally-controlled Red Evolution mic preamps with up to 63dB of ultra-clean gain, stereo linking, individual phantom power, high-pass filter and phase reverse

Dual-port Dante card for more channels at higher sample rates

Two discrete high-fidelity headphone outputs, Two instrument inputs on the front panel

Connect multiple digital sources using word clock I/O and loop-sync I/O

Specifications

Product Type
Audio Interface
Connectivity
Thunderbolt 3, Pro Tools | HD, Dante
Line Inputs
16 (D-sub)
Line Outputs
16
Monitor Outputs
2
Mic Preamps
2 (Red Evolution)
Gain Range
Up to 63dB
Phantom Power
Individual
Headphone Outputs
2 (Discrete, High-Fidelity)
Instrument Inputs
2 (Front Panel)
Digital Connectivity
Word Clock I/O, Loop-Sync I/O
Dante Card
Dual-Port

Pros & Cons

👍 Pros

  • At lower gain settings, the Red Evolution preamps are exceptionally transparent — acoustic instruments and vocals sit naturally in a mix without needing EQ correction for preamp coloration.
  • The simultaneous Thunderbolt 3, Pro Tools HD, and Dante connectivity means the interface adapts to hybrid studio routing without reconfiguration or add-on cards.
  • Individual phantom power and high-pass filter per preamp channel enables precise gain staging when mixing mic types on a single session.
  • The D-sub line I/O density — 16 in, 16 out plus two monitor outputs — makes patchbay integration in a traditional rack studio straightforward and clean.
  • Word clock and loop-sync I/O provide robust clocking options for large systems where multiple converters must stay locked.

👎 Cons

  • Only two mic preamp channels limits the Red 16Line as a standalone front end — high-channel-count sessions still require external preamps routed through the D-sub inputs.
  • The F/UTP shielding and dense feature set come in a form factor that assumes a fixed rack installation; it's not a practical interface for mobile or location recording.
  • Dante configuration adds setup complexity that requires familiarity with Dante Controller software — not a plug-and-play experience for engineers new to IP audio routing.
  • At the top of its gain range (63dB), the Red Evolution preamps may exhibit slightly elevated noise floor compared to dedicated boutique mic pre units in the same price tier.

Frequently Asked Questions

The Red Evolution preamps deliver up to 63dB of gain — sufficient for most ribbon mics in a treated room, though extremely low-output ribbons in a loud live environment may push them close to their ceiling. For typical condenser and dynamic mic work, the gain is clean and composed well below that ceiling.
The Red 16Line connects natively to Pro Tools | HD via its dedicated HDX/HD Native connectivity without requiring add-on option cards. It also runs Thunderbolt 3 and Dante simultaneously, meaning you can feed Pro Tools, a DAW on a Thunderbolt Mac, and a Dante network all at once from a single unit.
Yes — the ultra-low round-trip latency via Thunderbolt 3 is designed to let you track through plug-in processing in real time without a dedicated DSP card. At low buffer settings, the latency is transparent enough that most performers won't notice monitoring through a channel strip or light reverb.
Each of the two Red Evolution mic preamps has individual phantom power control, along with a high-pass filter and phase reverse per channel. This matters in sessions where you're running a condenser alongside a dynamic or ribbon on the same interface.
The dual-port Dante card maintains high channel counts at elevated sample rates, making the Red 16Line viable for large-format sessions running at 88.2kHz or 96kHz where some interfaces drop Dante channel count significantly. It keeps your network audio infrastructure intact without sacrificing fidelity.