M-Audio

M-Audio Oxygen 49 MKV MIDI Keyboard Controller Beat Pads Software Suite

4.4 (355 reviews)

The M-Audio Oxygen 49 MKV pairs 49 full-size keys and NKS integration with a complete production software suite.

$169.00*$199.00Save 15%
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*Price sourced from Amazon.com. Last updated:Jun 04, 2026.Price and availability are subject to change.

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Overview

The M-Audio Oxygen 49 MKV is a USB MIDI keyboard controller built for music producers who want comprehensive hands-on control without occupying an entire desk. Its 49 velocity-sensitive full-size keys strike a practical balance — enough range for expressive two-handed playing and chord work, while remaining compact enough for a home studio. Flanking the keybed are pitch and modulation wheels, and the top panel hosts 8 assignable knobs and 9 assignable faders that provide tactile control over virtual synth parameters, effect plugins, and DAW mixer channels. Two banks of 8 backlit velocity-sensitive drum pads with Note Repeat round out the hardware, making it equally capable for beat production, clip launching, and triggering samples.

What sets the MKV generation apart is its Native Kontrol Standard (NKS) integration — a partnership with Native Instruments that lets you browse and control NKS-compatible presets and sound libraries directly from the controller. Buyers also choose one of three complimentary Komplete 15 Select bundles (Beats, Band, or Electronic), which significantly expands the instrument's sound palette out of the box. Additional bundled software includes MPC Beats, Ableton Live Lite, AIR Music Tech's Hybrid 3 synthesizer and Mini Grand piano plugin, and five Akai Professional MPC Expansion packs. Smart Chord and Smart Scale modes help less experienced players stay in key, while the built-in arpeggiator adds rhythmic movement to any patch. A sustain pedal input on the rear panel and USB bus power complete a controller that genuinely delivers a full production toolkit at an accessible price.

Key Features

Recording Studio Equipment Essential - MIDI controller with 49 velocity-sensitive full-size piano style keys delivers a natural response that gets the best from virtual sampler and synthesizer plugins

Native Kontrol Standard (NKS) Integration - M-AUDIO and Native Instruments have partnered to bring NKS support to the Oxygen series, get ready to Kontrol straight from your Oxygen keyboard

Choose Your Exclusive Complimentary NKS Bundle - Browse and control Native Instruments presets and sound libraries; select one of three curated Komplete 15 Select bundles; Beats, Band, or Electronic

Make Better Beats with these Beat Maker Must Haves - 2 banks of 8 backlit velocity sensitive drum pads with Note Repeat - for beat production, clip launching, soundboard triggering and more

Get Hands-on with Your Music Studio Equipment - 8 assignable knobs and 9 assignable faders for tactile MIDI control of virtual synth parameters, effect plugins, DAW controls and more

Every Tool You Need - Effortless auto-mapping for DAW controls and plugin parameters; Smart Chord and Smart Scale modes; Arpeggiator; pitch and mod wheels; sustain pedal input; USB MIDI cable included

Complete Software Production Package Included - MPC Beats, Ableton Live Lite, 2 virtual instruments from AIR Music Tech (Hybrid 3 and Mini Grand) and 5 Akai Professional MPC Expansion packs

Follow the included download card to visit the M-AUDIO website and obtain all supplied software and firmware updates

Specifications

Brand
M-Audio
Model
Oxygen 49 MKV
Keys
49 velocity-sensitive full-size synth-action
Drum Pads
16 (2 banks of 8) backlit, velocity-sensitive with Note Repeat
Knobs
8 assignable
Faders
9 assignable
Wheels
Pitch and Modulation
Pedal Input
1/4-inch sustain pedal
Connectivity
USB (bus powered)
NKS Compatible
Yes
Smart Features
Smart Chord, Smart Scale, Arpeggiator
Bundled Software
MPC Beats, Ableton Live Lite, AIR Hybrid 3, AIR Mini Grand, 5 MPC Expansion packs, Komplete 15 Select bundle (choice of 3)

Pros & Cons

👍 Pros

  • 49 full-size velocity-sensitive keys provide a wide enough range for two-handed playing and realistic performance
  • 16 backlit velocity-sensitive drum pads across two banks with Note Repeat for versatile beat production
  • 17 assignable controls (8 knobs and 9 faders) offer hands-on mixing and parameter adjustment
  • NKS integration with a complimentary Komplete 15 Select bundle adds substantial sound library value
  • Comprehensive bundled software including MPC Beats, Ableton Live Lite, and two AIR virtual instruments

👎 Cons

  • Keys are synth-action and unweighted, which may disappoint pianists who prefer hammer-action feel
  • Connects via USB only — no standalone MIDI DIN output for controlling hardware synths without a computer
  • No aftertouch on the keybed limits expressive playing techniques
  • Bundled software requires downloading from the M-Audio website rather than being available on physical media
  • Faders and knobs are plastic and may feel less durable than metal controls on higher-end controllers

Frequently Asked Questions

It is a USB class-compliant MIDI controller, so it works out of the box with most DAWs. However, you should visit the M-Audio website using the included download card to obtain the bundled software and any firmware updates.
The controller features effortless auto-mapping for DAW controls and plugin parameters. It includes Ableton Live Lite and MPC Beats, and is compatible with all major DAWs that accept USB MIDI input.
Native Kontrol Standard (NKS) integration lets you browse and control Native Instruments presets and sound libraries directly from the Oxygen keyboard. You can also choose one of three curated Komplete 15 Select bundles (Beats, Band, or Electronic) as a complimentary download.
No, the 49 keys are velocity-sensitive but synth-action (unweighted) piano-style keys. They are full-size but do not simulate the resistance of a weighted or hammer-action keyboard.
Yes, the Oxygen 49 MKV has a dedicated 1/4-inch sustain pedal input on the rear panel.