Brands Guides About
Logitech 910-006234 Signature M650L Left Wireless Mouse — main product image
Logitech 910-006234 Signature M650L Left Wireless Mouse
Logitech 910-006234 Signature M650L Left Wireless Mouse
Logitech 910-006234 Signature M650L Left Wireless Mouse
Logitech 910-006234 Signature M650L Left Wireless Mouse
Logitech 910-006234 Signature M650L Left Wireless Mouse
Logitech 910-006234 Signature M650L Left Wireless Mouse
Logitech

Logitech 910-006234 Signature M650L Left Wireless Mouse

★★★★★4.6 (11740 reviews)

Logitech's Signature M650L Left delivers ergonomic comfort, silent clicks, and smart scrolling designed specifically for left-handed users.

$39.99*$51.23Save 21%
Check availability

*Price sourced from Amazon.com. Last updated:Jul 14, 2026.Price and availability are subject to change.

Affiliate Disclosure: Studio Supplies may earn a commission from qualifying purchases made through links on this page, at no additional cost to you. This helps support our editorial team.

Notice a mistake? Let Us Know

Overview

The Logitech Signature M650L Left Wireless Mouse addresses a longstanding gap in the peripheral market: a full-featured, ergonomic wireless mouse designed from the ground up for left-handed users with larger hands. The contoured body places a soft thumb rest and textured rubber side grips exactly where a left hand naturally rests, reducing strain during long work sessions. SilentTouch technology cuts click noise by 90 percent compared to standard mice, making it a considerate choice for open offices, shared desks, and late-night work without disturbing those nearby.

The adaptive SmartWheel is a standout productivity feature, switching between precise line-by-line scrolling for spreadsheets and documents and a fast free-spin mode for flying through lengthy web pages or files. Two customizable side buttons can be programmed through Logitech Options+ on Windows or macOS to trigger frequently used shortcuts, streamlining common workflows. Connectivity is flexible with both Bluetooth Low Energy and Logi Bolt USB receiver options, and compatibility spans Windows, macOS, Linux, ChromeOS, iPadOS, and Android. With up to 24 months of battery life from a single AA battery and construction that includes certified post-consumer recycled plastic, the M650L Left combines thoughtful ergonomics with practical, low-maintenance reliability.

Key Features

Scroll smarter: With Logitech Signature M650 Wireless Mouse you get line-by-line precision for documents and super-fast scrolling for long web pages; simply switch modes with a flick of the SmartWheel

Left handed design: This comfortable full size mouse is designed for larger hands, for the optimal fit for left handed users

Upgrade your comfort: This work mouse provides long hours of comfort thanks to a contoured shape, soft thumb area, and rubber side grips that keep your hand snug and in place

Connect the way you like: Connect this cordless computer mouse in an instant via Bluetooth Low Energy or Logi Bolt USB receiver

Less noise, more focus: Whether working at the office or at home, Logitech Signature M650 is a quiet mouse, allowing you to enjoy 90 percent less click noise with SilentTouch technology*

Customizable side buttons: Customize the side buttons on the computer mouse with Logitech Options+, available on Windows and macOS, to your favorite shortcuts – like back/forward or copy/paste

Works on multiple platforms: Experience seamless compatibility with Windows, macOS, Linux, ChromeOS, iPadOS, and Android operating systems; it is also a Works with Chromebook certified product

Plastic parts in Signature M650 L Left include certified post-consumer recycled plastic (Graphite:68%; Off-White: 27%****)

Specifications

Brand
Logitech
Model
910-006234
Hand Orientation
Left-Handed
Size
Full Size (Large)
Connectivity
Bluetooth Low Energy, Logi Bolt USB Receiver
Scrolling
SmartWheel (Line-by-Line & Free-Spin)
Click Technology
SilentTouch (90% Less Noise)
Buttons
Customizable Side Buttons (via Logitech Options+)
Battery Life
24 Months
Compatibility
Windows, macOS, Linux, ChromeOS, iPadOS, Android
Recycled Materials
Graphite: 68%, Off-White: 27% Post-Consumer Recycled Plastic

Pros & Cons

👍 Pros

  • Purpose-built left-handed ergonomic shape with contoured thumb area and rubber grips
  • SilentTouch technology reduces click noise by 90%, ideal for shared workspaces
  • SmartWheel offers both precise and fast-scroll modes in one wheel
  • Dual connectivity via Bluetooth Low Energy and Logi Bolt USB receiver
  • 24-month battery life minimizes maintenance

👎 Cons

  • Designed exclusively for left-handed users, not ambidextrous
  • Customizable buttons require Logitech Options+ software, which is only available on Windows and macOS
  • Uses a single AA battery rather than a built-in rechargeable cell
  • Only two side buttons limits the number of available custom shortcuts

Frequently Asked Questions

Yes, the M650L Left has a contoured body designed exclusively for left-handed users with larger hands, featuring a soft thumb rest and rubber side grips positioned for left-hand ergonomics.
The SmartWheel offers two modes — line-by-line precision scrolling for documents and spreadsheets, and a super-fast free-spin mode for quickly navigating long web pages. You switch between them with a flick of the wheel.
The M650L Left connects via Bluetooth Low Energy or the included Logi Bolt USB receiver, giving you flexibility depending on your setup and available ports.
The mouse runs for up to 24 months on a single AA battery, so battery changes are infrequent.
Yes, using the free Logitech Options+ software on Windows or macOS, you can assign custom shortcuts like back/forward, copy/paste, or other frequently used actions to the side buttons.

Related Products