Synology

Synology DiskStation DS1621xs+ 6-Bay NAS (Diskless)

4.7 (108 reviews)

The DS1621xs+ delivers over 3,100 MB/s sequential read with built-in 10GbE and NVMe cache — SMB-grade NAS throughput that doesn't require a separate networking card to unlock.

$2,199.99*
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*Price sourced from Amazon.com. Last updated:Jul 14, 2026.Price and availability are subject to change.

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Overview

The Synology DS1621xs+ occupies a specific and well-defined position in the NAS market: it is the entry point to genuine 10GbE networking in a 6-bay tower form factor, without requiring the user to install an add-in card to reach usable throughput. Built-in 10GbE combined with two dedicated M.2 2280 NVMe SSD cache slots and an optional high-speed NIC yields a rated sequential read of over 3,100 MB/s — a figure that means real-world network transfers of large files are limited by drive speed rather than network bandwidth for the first time at this scale. The six SATA bays support both 3.5-inch HDDs and 2.5-inch SSDs, and expansion via Synology DX units scales the platform to 16 total drives, giving IT departments a growth path that doesn't require forklift upgrades.

Synology's DSM 7 operating system is the DS1621xs+'s strongest asset alongside its hardware. Active Backup for Business provides agentless endpoint and VMware backup with no per-seat licensing — a recurring cost center that this platform eliminates. Snapshot Replication enables near-instant recovery point objectives for critical volumes. Virtual Machine Manager supports hosted guest VMs for edge computing or infrastructure consolidation. The combination makes the DS1621xs+ a genuine platform for small and mid-sized businesses that need high-throughput shared storage, backup infrastructure, and light virtualization in a single manageable appliance. For media production environments running Premiere or Resolve workflows over 10GbE, or for IT shops standardizing on Synology's ecosystem, this unit represents a coherent, well-supported investment rather than a commodity storage box.

Key Features

Combine built-in 10GbE and optional high-speed NIC for over 3,100 MB/s sequential read performance

Built-in M.2 2280 NVMe SSD slots permit cache acceleration without using storage drive bays

Flexibly scale up to 16 drives to increase storage capacity as demand grows

Back up critical data and reduce your Recovery Time Objective (RTO) with Snapshot Replication

Use virtualization storage tools to complete your SAN or run virtual machines on a full-featured hypervisor

Specifications

Drive Bays
6
Built-in 10GbE
Yes
M.2 NVMe SSD Slots
2 x M.2 2280 (cache only)
Max Drive Scalability
Up to 16 drives (with expansion units)
Sequential Read Performance
Over 3,100 MB/s (with optional high-speed NIC)
Operating System
Synology DSM 7
Virtualization
Virtual Machine Manager (VMM) supported
Backup Software
Active Backup for Business (included)

Pros & Cons

👍 Pros

  • Built-in 10GbE eliminates the need to purchase a separate NIC to reach multi-gigabit throughput — competing 6-bay units at this tier typically require an add-in card
  • Two dedicated M.2 NVMe SSD cache slots preserve all six drive bays for storage while still enabling cache acceleration — no tray-slot trade-off
  • Sequential read performance rated over 3,100 MB/s with combined 10GbE and optional high-speed NIC, making it viable for 4K/8K video editing workflows over the network
  • Scalable to 16 drives via expansion units — the platform grows with storage demand without hardware replacement
  • Active Backup for Business is included in DSM with no per-seat fee, representing meaningful cost savings over third-party backup licensing

👎 Cons

  • Diskless at this price point means drive costs are additive — a fully populated 6-bay build with enterprise drives represents a substantial total investment
  • NVMe slots are cache-only and cannot be used as primary storage volumes, limiting flexibility compared to NAS units that treat M.2 slots as general-purpose bays
  • The optional high-speed NIC required to achieve the full 3,100 MB/s throughput specification is a separate purchase — the base unit alone won't reach that number
  • Expansion to 16 drives requires purchasing Synology DX expansion units specifically — no third-party expansion shelf compatibility
  • Higher power draw and fan noise than entry-level NAS units make this a data-center or server-room class device rather than a living space appliance

Frequently Asked Questions

Standard NAS units with 1GbE top out at roughly 125 MB/s sustained transfer — a hard ceiling imposed by the network link, not the drives. The DS1621xs+'s built-in 10GbE port raises that ceiling to 1,250 MB/s, and combined with NVMe SSD cache and a high-speed NIC, Synology rates sequential read at over 3,100 MB/s. For users transferring large video files, running virtual machines, or serving multiple concurrent users, this eliminates the bottleneck that makes 1GbE NAS frustrating.
The DS1621xs+ includes two dedicated M.2 2280 NVMe SSD slots on the motherboard, physically separate from the six 3.5-inch drive bays. These slots are exclusively for read/write cache acceleration via Synology's SSD Cache feature — they do not appear as usable storage volumes. By dedicating slots to cache instead of bays, you preserve the full six bays for spinning disk or SSD storage capacity.
Yes — the DS1621xs+ supports Synology DX expansion units, scaling to 16 total drives. This expansion path matters for businesses that want to start with a 6-bay footprint and grow storage capacity without replacing the NAS unit. Note that expansion requires compatible Synology DX shelves connected via eSATA.
Synology's Virtual Machine Manager (VMM) hypervisor runs on DSM 7 and is supported on the DS1621xs+. The unit can host guest VMs for light workloads — infrastructure services, test environments, edge computing tasks. For production virtualization workloads with multiple concurrent VMs under heavy load, a dedicated hypervisor host will outperform it, but for IT environments that want to consolidate NAS and basic VM hosting, it's a capable platform.
Snapshot Replication is included at the DSM level — snapshots can be taken at defined intervals with recovery time objective (RTO) measured in seconds for individual files or entire volumes. Hyper Backup supports off-site replication to cloud targets, remote Synology units, or rsync destinations. Active Backup for Business adds agentless backup for Windows endpoints and VMware environments without per-seat licensing fees.