Synology

Synology DS1621+ DiskStation NAS - High Performance Storage

4.7 (195 reviews)
4K

AMD Ryzen-powered 6-bay NAS that delivers enterprise-grade read/write performance and scales to 16 drives without a chassis swap.

$1,270.48*
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*Price sourced from Amazon.com. Last updated:Jul 14, 2026.Price and availability are subject to change.

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Overview

The Synology DS1621+ is the answer to a specific question: what happens when a workgroup NAS is powered by a real desktop-class CPU instead of an embedded Atom derivative? The AMD Ryzen V1500B at its core changes the performance ceiling fundamentally — 174% higher 4K random read IOPS and 76% faster sequential write speeds over its predecessor aren't marketing rounding errors, they reflect the difference between a processor that can handle concurrent requests without queuing and one that can't. For environments running virtual machines, multi-user SMB shares, iSCSI LUNs, or containerized applications through DSM's Docker integration, that CPU headroom is the difference between a NAS that keeps up and one that becomes the bottleneck.

The hardware architecture is built for longevity. The dual M.2 NVMe slots for SSD caching sit outside the drive bay count — a deliberate design choice that lets you add cache acceleration without trading storage capacity. The single PCIe 3.0 slot accepts Synology's 10GbE NICs, which is the logical next upgrade once the CPU stops being the constraint. And the two eSATA expansion ports support up to two DX517 units, growing the system to 16 drives without a chassis replacement. Synology's DSM platform ties it together with a no-additional-cost backup suite that covers cloud replication, bare-metal Windows backup, VM protection, and snapshot-based recovery — making the DS1621+ a credible alternative to dedicated backup appliances for small-to-medium environments that need enterprise data protection without enterprise licensing fees.

Key Features

Accelerated Performance: 174% higher 4K random read IOPS and 76% faster sequential write speeds compared to its predecessor

Maximize Performance: Turbocharge HDD arrays by 20x or more2 without occupying drive bays using dual built-in M.2 slots for NVMe SSD cache

Easy Expansion: Scale-up on-demand to 16 drives with two DX517 expansion units

Includes Everything to Protect Your Data: Back up critical data to and from public clouds, Windows PCs and servers, virtual machines, and data on the NAS with Synology Active Backup suite, Hyper Backup, and Snapshot Replication

Ready for 10GbE: Add in a 10GbE SFP+ or RJ-45 NIC to instantly increase network bandwidth based on your existing infrastructure

Specifications

Model
DS1621+
Type
DiskStation NAS
Performance (4K Random Read IOPS)
174% higher than predecessor
Performance (Sequential Write Speed)
76% faster than predecessor
M.2 Slots
Dual built-in for NVMe SSD cache
Drive Expansion Capability
Up to 16 drives with two DX517 units
Backup Solutions Included
Synology Active Backup suite, Hyper Backup, Snapshot Replication
Network Bandwidth
Ready for 10GbE (SFP+ or RJ-45 NIC add-in)

Pros & Cons

👍 Pros

  • AMD Ryzen V1500B delivers substantially more CPU headroom than competing NAS devices at this price point, handling multi-user access and VMs without throttling.
  • Dual M.2 NVMe slots for SSD cache are physically separate from drive bays, meaning caching acceleration costs you nothing in raw storage capacity.
  • PCIe expansion slot enables 10GbE upgrades, future-proofing the unit against network bottlenecks as storage demands grow.
  • Scales from 6 to 16 drives via two DX517 units — a genuine growth path without replacing the chassis.
  • Synology's DSM operating system is mature, actively maintained, and includes a full backup suite (Active Backup, Hyper Backup, Snapshot Replication) at no additional licensing cost.

👎 Cons

  • No 10GbE onboard at this price — adding a NIC is an additional cost that should be budgeted alongside the unit purchase for high-throughput use cases.
  • RAM is limited at stock configuration; demanding workloads like multiple simultaneous VMs or heavy Docker container usage will require an upgrade to reach full performance potential.
  • The Ryzen V1500B lacks hardware video transcoding acceleration, so Plex or media server workloads rely on software transcoding, which consumes significant CPU under load.
  • Drives are not included — total deployment cost at scale with 6-16 enterprise HDDs is substantially higher than the NAS unit price alone.

Frequently Asked Questions

The DS1621+ runs an AMD Ryzen V1500B — a quad-core, 8-thread embedded processor clocked at 2.2 GHz. This is a significant step above the Atom-class CPUs in most NAS devices at this tier, which translates directly to faster virtual machine performance, more simultaneous users without throughput degradation, and responsive transcoding without dedicated hardware acceleration.
Synology rates it at 174% higher 4K random read IOPS and 76% faster sequential write speeds versus the previous generation. In practical terms, this means faster file access under multi-user load, quicker backup jobs, and meaningfully improved performance for iSCSI workloads or database hosting.
The two built-in M.2 2280 slots are dedicated solely to NVMe SSD caching — they do not consume any of the six HDD bays. Adding NVMe cache can accelerate HDD array performance by up to 20x for frequently accessed data, effectively capping the latency gap between spinning disk and SSD for hot data.
The DS1621+ does not ship with 10GbE onboard, but it includes a PCIe 3.0 slot that accepts Synology's 10GbE NIC add-in cards — both SFP+ and RJ-45 options are available. Adding 10GbE eliminates the network as the bottleneck for high-throughput workloads like 4K video editing over NAS.
Two DX517 expansion units can be daisy-chained via the eSATA expansion ports, bringing total drive capacity to 16 bays. Expansion is hot-add — you're scaling storage without downtime or data migration, which matters for always-on production environments.